Table 1 Function of Th17 cells in infectious disease models at the mucosa

Klebsiella pneumoniae

Respiratory

Protective

Induction of chemokines, antimicrobials, and neutrophil recruitment^{16, 17, 18, 65}

Citrobacter rodentium

Gut

Protective

Induction of chemokines and antimicrobials^{29, 67, 68}

Porphyromonas gingivalis

Oral cavity

Protective

Neutrophil recruitment^{69, 70}

Bordetella pertussis

Respiratory

Exacerbation

Inflammation and pathology^{35, 45}

Helicobacter pylori

Gut

Exacerbation

Inflammatory infiltration of neutrophils^{72, 73}

Mycobacterium tuberculosis Mycobacterium bovis BCG

Respiratory

No effect on protection

Impacts granuloma formation^{41, 51, 65}

Mycoplasma pneumonia

Respiratory

Protective

Recruitment of neutrophils⁷⁴

Salmonella typhimurium

Gut

No effect on bacterial burden at the site of primary infection

Impacts epithelial barrier function, recruitment of neutrophils, and increased bacterial translocation to lymph nodes⁷⁵

Candida albicans

Oral cavity

Protective

Induction of chemokines and antimicrobials and neutrophil recruitment^{78, 79}

Candida albicans

Gut

Exacerbation

Increased neutrophilic recruitment⁴⁹

Pneumocystis carinii

Respiratory

Protective

Reduced chemokine induction and recruitment of effector CD4 T cells⁸³

Aspergillus fumigatus

Respiratory

Protective/exacerbation

Reduced chemokine induction and neutrophil recruitment⁸⁴

IL-17 exacerbates disease in NADPH oxidase-deficient mice⁸⁵

Herpes virus

Respiratory

Exacerbation

Recruitment of neutrophils and pathology^{46, 88}

Human rhinovirus

Respiratory

Exacerbation

Recruitment of neutrophils and effector T cells and pathology⁸⁹