Figure 2
From: Advances in mast cell biology: new understanding of heterogeneity and function
Mast cells (MCs) as effectors in homeostasis and disease. MCs in various tissue microenvironments are poised to respond to an array of stimuli by releasing numerous mediators. These regulate both physiological (e.g., wound healing, hair follicle cycling, angiogenesis, bone remodeling) and pathological process (e.g., allergic reactions) by influencing various cell types. Mechanisms of action of certain MC mediators on their targets maybe similar, but the outcome can differ depending on circumstances and site (e.g., wound healing vs. airway remodeling, or bronchoconstriction in airway vs. motility disturbances in intestine).
