Figure 1
From: MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
An overview of MEP1A polymorphisms. The polymorphic sites in the human MEP1A gene are shown in the context of the multidomain structure of the meprin-α subunit. Meprin protein domains are S, signal peptide; Pro, propeptide; Astacin, catalytic protease domain; MAM, meprin/A5-protein/protein-tyrosine phosphate μ; TRAF, TNF-α receptor-associated factor; I, inserted; EGF, epidermal growth factor; TM, transmembrane; and C, cytosolic tail. The AUG start and UGA stop codons and Poly A are italicized. The SNPs and the 12-bp insert are indicated by their nucleotide positions. Affected amino-acid residues and their position in the protein sequence are shown below the subunit structure. UC-associated SNPs are highlighted in bold. Reference mRNA sequence, GenBank NM_005588, which lacks the 12-bp insert. SNP, single-nucleotide polymorphism; TNF, tumor necrosis factor; UC, ulcerative colitis.
