Figure 2
From: MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
Expression of meprin-α, meprin-β, and villin-1 in the intestinal mucosa of IBD patients and healthy controls. mRNA levels, as determined by quantitative RT-PCR, are shown relative to the average colonic expression levels of meprin-α in healthy controls. (a) Endoscopic biopsies of three control individuals collected from the terminal ileum, cecum, proximal and distal transverse colon, sigmoid colon, and rectum. (b) Endoscopic biopsies from the sigmoid colon from not affected and inflamed mucosal areas of CD patients, UC patients, and healthy controls (n=14 in each group). Shown are individual values and mean. ***P<0.001, **P<0.01, compared with controls (Kruskal–Wallis and Dunn's multiple comparison test). (c) Ratio of meprin-α/villin-1 mRNA levels in mucosa in CD and UC patients as compared with controls. IBD, inflammatory bowel disease; CD, Crohn's disease; RT-PCR, reverse transcription PCR; UC, ulcerative colitis.
