Figure 4
From: MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
Meprin αKO mice are more severely affected than WT mice by DSS treatment. (a) Body weight loss in WT and meprin αKO mice was monitored over a 7-day period (n=7 mice per group). The meprin αKO DSS group lost a greater percent of body weight than the WT DSS group over days 4–7 (*P<0.05; **P<0.01; ***P<0.001). (b) Occult blood scores for both WT and meprin αKO DSS groups on day 7 showed significantly higher bleeding than their corresponding control groups (n=7 mice per group; *P<0.01; **P<0.001). (c) Disease activity index (DAI) for the 3.5% DSS colitis model. WT and meprin αKO controls maintained DAI scores of 0–0.5 over the 7-day period. The DAI for the meprin αKO DSS group was significantly increased starting on day 4 (*P<0.001; compared with controls), whereas the WT DSS DAI increased day 5 onwards (**P<0.01; *P<0.001; compared with controls). There was a significant difference in the DAIs of the two DSS-treated groups from days 4 to 7 (***P<0.001). DSS, dextran sulfate sodium; WT, wild type.
