Figure 6
From: MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
Colon cytokine and chemokine levels of WT and αKO mice treated with or without DSS were measured on day 5 (n=5 per group). Both the DSS-treated groups had significant elevations in their cytokine levels compared with their corresponding controls (WT DSS treated vs. control, *P<0.03; αKO DSS treated vs. control, #P<0.05). (a) IL-6 levels were greatly elevated upon DSS treatment, in both WT and αKO mice, to significantly higher levels in the latter (**P<0.0001). (b–d) There were significant increases in the levels of IL-12 (**P<0.01), MCP-1 (**P<0.00007), and RANTES (**P<0.02), in the DSS-treated αKO colons compared with those of the DSS-treated WT group. (e) IL-10, an anti-inflammatory cytokine, was also elevated in both genotypes after DSS treatment; meprin αKO colons had significantly higher levels of IL-10 (**P<0.03). DSS, dextran sulfate sodium; MCP-1, monocyte chemotactic protein-1; WT, wild type.
