Figure 7
From: MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
Meprin αKO mice have greater systemic inflammation than WT mice. (a) Serum nitric oxide levels of all the four groups were measured throughout the course of the study from days 1 to 5. Compared with its control group, DSS-treated meprin αKO mice showed significantly higher levels as early as day 1(#P<0.05), whereas in the WT DSS-treated mouse, values were not elevated until day 5 (*P<0.05). The nitrite levels in meprin αKO mice were significantly higher than the WT DSS-treated group on days 4 and 5 (n=6; **P<0.02). (b–e) The DSS-treated groups had increased levels of serum cytokines compared with their respective water controls (n=7–15 mice per group; WT DSS treated vs. control, *P<0.03; αKO DSS treated vs. control, #P<0.05). IL-1β and IL-6 levels were markedly elevated in αKO compared with WT serum after DSS treatment (**P<0.04 and P<0.001, respectively). DSS-treated αKO mice also had significantly higher levels of MCP-1 (**P<0.05) and RANTES (**P<0.05) than the DSS-treated WT group. DSS, dextran sulfate sodium; IL, interleukin; MCP-1, monocyte chemotactic protein-1; WT, wild type.
