Figure 3 | Mucosal Immunology

Figure 3

From: Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection

Figure 3

High frequencies of T cells from uninfected pigtail macaques (PTMs) produce IL-17 compared with rhesus macaques (RMs). (a) Frequencies of CD4+ interferon γ (IFNγ)-producing T cells in blood; (b) frequencies of CD8+ IFNγ-producing T cells in blood; (c) frequencies of CD4+ IL-17-producing T cells in blood and necropsy tissues; (d) frequencies of CD8+ IL-17-producing T cells in blood and necropsy tissues; and (e) frequencies of CD4+ vs. CD8+ IL-17-producing T cells in blood of PTM. Correlation (r) determined by Spearman's rank correlation. All samples were stimulated with phorbol myristate acetate and ionomycin. PTM, circles and RM, triangles. Horizontal bars indicate median. P-values from Mann–Whitney U-test. Ax LN, axillary lymph node; Ing LN, inguinal LN; Mes LN, mesenteric LN; PBMC, peripheral blood mononuclear cell.

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