Figure 5 | Mucosal Immunology

Figure 5

From: Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection

Figure 5

Uninfected pigtail macaques (PTMs) have increased damage to the tight epithelial barrier and high levels of lipopolysaccharide (LPS) in the lamina propria of the colon. (a) Representative claudin-3 staining (brown) in colon of PTM; (b) representative claudin-3 staining (brown) in colon of rhesus macaques (RMs); (c) ratio of measurements of breached epithelial (no claudin) to intact epithelial (claudin) cells in either PTM or RM; (d) representative LPS staining (brown) in colon of PTM; (e) representative LPS staining (brown) in colon of RM; and (f) area of colon lamina propria LPS measured in PTM and RM. PTM, circles, RM, triangles. Horizontal bars indicate median. P-values from Mann–Whitney U-test.

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