Figure 6
Breaches in the colon correlate with microbial translocation and microbial translocation correlates with immune activation in the colon of uninfected pigtail macaques (PTMs). (a) The breach/intact ratio of the colon, as measured by claudin, significantly correlates with the amount of microbial translocation into the lamina propria of the colon of PTM. (b) The amount of MxA (a specific type-I interferon-responsive gene) in the colon, as measured by immunohistochemistry staining, significantly correlates with the amount of microbial translocation into the colon of PTM. Correlations determined by Spearman's rank correlation. Lines indicate linear regression. LPS, lipopolysaccharide.
