Figure 1
From: Interleukin-25 production is differently regulated by TNF-α and TGF-β1 in the human gut
Interleukin (IL)-25 protein synthesis is diminished in the inflamed gut of patients with inflammatory bowel disease (IBD). (a) Quantitative analysis of IL-25 protein expression in mucosal samples taken from 18 healthy controls (HC), 23 patients with ulcerative colitis (UC), and 15 patients with Crohn's disease (CD) as measured by enzyme-linked immunosorbent assay (ELISA). Data are expressed as mean±s.d.; *P<0.001. (b) Total proteins extracted from IBD mucosal biopsies taken from involved and uninvolved areas of seven patients with UC and two patients with CD were measured for IL-25 protein content by ELISA. Data are expressed as mean±s.d.; *P<0.004. (c) IL-25 protein was quantified in total proteins extracted from inflamed colonic biopsies of five IBD patients receiving no therapy (w/o therapy) and seven IBD patients treated with mesalazine (5-ASA) or mesalazine+steroids by ELISA. Data are expressed as mean±s.d. NS, not significant.
