Figure 3 | Mucosal Immunology

Figure 3

From: Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia

Figure 3

Frequencies of leukocyte subsets in CD11c-TL1A transgenic (tg) mice and activation status of CD4+ T cells. (a) Representative (n=5) flow cytometric plots of spleen cells from tg or wild-type (wt) mice demonstrating similar frequencies of CD4+ T cells, CD8+ T cells, macrophages (CD11b+), dendritic cells (CD11c high), B cells (CD19+), and natural killer (NK) cells (NK1.1+CD3−) in tg and wt mice. However, fewer invariant natural killer T (NKT) cells (NK1.1+ CD3+ or CD1d/α-galactosylceramide (αGalCer) tetramer+) were present in CD11c-TL1A tg mice. (b) Representative flow cytometric plots showing expression of activation/memory markers on peripheral CD4+Foxp3− cells from wt and tg mice (7–13-week-old mice; the data shown are representative of five mice per group).

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