Figure 2 | Mucosal Immunology

Figure 2

From: Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice

Figure 2

Depletion of CD11b+, but not CD11c+ antigen-presenting cells (APCs), decreases T-cell proliferation in cervical lymph nodes (CLNs) after sublingual administration of PSC-OVA. (a) Percentages of CD11b+ and CD11c+ cells from oral/lingual tissues in CD11b or CD11c-DTR mice after diphtheria toxin (DT) treatment. (b) In vivo proliferation in CLNs of ovalbumin (OVA)-specific CD4+ T cells adoptively transferred into phosphate-buffer saline (PBS)- or DT-treated CD11b or CD11c-DTR mice, receiving subsequently by the sublingual route either polysaccharidic core (PSC) or PSC-OVA. Data shown are compiled from two independent experiments. **P<0.01.

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