Figure 4
From: Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis
The role of eicosanoids in regulating death of infected macrophages. (a) Simplified version of eicosanoid biosynthesis. Substrates and products are indicated in black text. Enzymes are in red, and receptors in blue. (b) The balance of prostanoid and lipoxin production determines the death modality of Mtb-infected macrophages. Excess production of LXA4 leads to necrosis. In contrast, when PGE2 production predominates, necrosis is inhibited and more apoptosis is the consequence. COX2, cyclooxygenase-2; cPLA2, cytosolic phospholipase A2; LXA4, lipoxin A4; Mtb, Mycobacterium tuberculosis; PGE2, prostaglandin E2; PGH prostaglandin H.
