Figure 8
From: Protective role of Toll-like receptor 4 in experimental gonococcal infection of female mice
Th17-type cytokine production is impaired in the TLR4-mutant mice. Relative expression of GAPDH, RORGT, STAT3, IL-6, IL-17A, IL-17E, IL-17F, IL-17 RB, IL-21, IL-22, IL-23A, and IL-23R after intravaginal inoculation with FA1090. Total RNA was extracted from vaginal washes and subjected to relative real-time PCR, as described in the text. A relative change of twofold or greater between infected BALB/c vs. infected BALB/c-Lpsd mice was considered significant. These results are representative of two independent experiments. GAPDH, glyceraldehyde 3-phosphate dehydrogenase; IL, interleukin; STAT3, signal transducer and activator of transcription 3; TLR4, Toll-like receptor-4.
