Figure 1
From: Integrative inflammasome activity in the regulation of intestinal mucosal immune responses
Activators of the inflammasomes. The NLRP3, NLRC4, NLRP1, AIM2, and NLRP6 inflammasomes are activated by sterile (host- and environmentally derived) and pathogen-derived noxious stimuli. Assembly of the NLRs or PYHINs, ASC, and pro-caspase-1 leads to the formation of a multi-protein structure: the inflammasome. Activation of the inflammasome leads to maturation and secretion of IL-1β and IL-18 as well as inflammatory cell death (pyroptosis). ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; MDP, muramyl dipeptide; MSU, monosodium urate; NLR, Nod-like receptor.
