Figure 2
HIV type-1 (HIV-1) translocation across penile explants. (a) A schematic representation of the experimental explant system (right) of different penile epithelia (left). (b) Mean±s.e.m. percentages of HIV-1 translocation (p24 in basal chamber/p24 in apical chamber × 100) following 1 h exposure of urethra, fossa, and glans explants to 1 × 106 peripheral blood mononuclear cell (PBMCs) infected with the primary clade B HIV-1 isolate V29 (black bars; maximal apical viral input of 1,000 pg p24) or exposure of urethral explants to cell-free HIV-1 V29 (gray bar; apical viral input of 5,000 pg p24). Results are derived from n=9 (HIV-1-infected PBMCs) and n=3 (cell-free HIV-1) explants. Statistical analysis: *P<0.0001, P=0.0319, and P=0.0329, urethra cell-associated vs. urethra cell-free, fossa cell-associated, and glans cell-associated, respectively.
