Figure 5
Myeloid differentiation factor 88 (MyD88) deletion in Scnn1b-transgenic (Scnn1b-Tg+) mice alters bronchoalveolar lavage (BAL) neutrophil- and macrophage-related inflammatory mediators. BAL cytokines in 5-day-, 10-day- and 4-week-old mice. The dotted line represents the assay lower limit of detection (LOD). n=4 for wild-type mice and n=6 for Scnn1b-Tg+ mice. Analysis of variance **P<0.005, *P<0.05 vs. age-matched MyD88+/−;Scnn1b-Tg− mice. #P<0.05 vs. MyD88+/−;Scnn1b-Tg+ mice. G-CSF, granulocyte colony-stimulating factor; KC, keratinocyte-derived cytokine; LIX, lipopolysaccharide-induced CXC chemokine; M-CSF, macrophage colony-stimulating factor; MIP, macrophage inflammatory protein; TNF, tumor necrosis factor.
