Figure 6
Myeloid differentiation factor 88 (MyD88) deletion does not modify mucus plugging, but promotes development of lymphoid aggregates in Scnn1b-transgenic (Scnn1b-Tg+) mice. (a–c) Semi-quantitative histopathology scores for mucus plugs and mucous secretory cells (Alcian blue–periodic acid-Schiff positive) in (a) neonatal trachea and (b, c) left lobe intrapulmonary main stem bronchus, at different time points. (d) Semi-quantitative histopathology scores for lymphoid aggregates (bronchial-associated lymphoid tissue). n=6, 8, 3, and 5 at 1–3 days (1–3d), n=5, 6, 4, and 8 at 5 days (5d), n=13, 5, 10, and 12 at 10 days (10d), n=5, 4, 5, and 9 at 4 weeks (4wk), and n=8, 8, 11, and 9 at 8 weeks (8wk) for MyD88+/−;Scnn1b-Tg−; MyD88−/−;Scnn1b-Tg−; MyD88+/−;Scnn1b-Tg+; and MyD88−/−;Scnn1b-Tg+ mice, respectively. Analysis of variance **P<0.005, *P<0.05 vs. MyD88+/−;Scnn1b-Tg− mice. #P<0.05 vs. MyD88+/−;Scnn1b-Tg+ mice.
