Figure 5
Early responses and lung allograft acceptance. Histological appearance (original magnification, ×100) of B6 grafts 30 days (d) after transplantation into (a) untreated (n=4) or (b) immunosuppressed (MR1 250 μg intraperitoneally (i.p.) day 0, CTLA4-Ig 200 μg i.p. day 2) CBA hosts (n=6). Histological appearance of B6 lung grafts, initially transplanted into immunosuppressed CBA hosts for (c) 30 days (n=3) or (d) 72 h (n=6) and then retransplanted into untreated CBA mouse shown 30 days after retransplantation. (e) Rejection scores (International Society of Heart and Lung Transplantation (ISHLT) grade A) for transplants shown in panels a, b, c, and d (**P<0.01).
