Figure 7
Time-resolved transcriptome signatures for the dynamic, region-specific mucosal responses to the colonizing microbiota. (a) The ingenuity protein–protein interaction network derived by plotting STEM (Short Time series Expression Miner) output genes involved in the temporal expression profiles involved in immune response in the jejunum (J), ileum (I), and colon (C). Transcriptional data was projected onto the interaction map. Red arrows refer to genes associated with inflammatory bowel disease. (b) Heat map of the genes that constitute the core regulatory network (n=6–11).
