Figure 3
Interleukin (IL)-17-producing lymphocytes produce IL-22, and IL-22-producing lymphocytes are lost after SIV infection and associated with mucosal barrier integrity. (a, b) The frequency of IL-22+ cells within IL-17-producing CD4+ T cells (left), CD8+ T cells (center), and CD3-CD8+ lymphocytes (right) in (a) colon and (b) mesenteric lymph nodes (MLNs). (c, d) The frequency of IL-22-producing CD4+ T cells (left), CD8+ T cells (center), and CD3-CD8+ lymphocytes (right) in uninfected (circles) or SIV-infected (triangles) RMs in (c) colon and (d) MLNs. (e, f) The frequency of IL-22-producing CD4+ T cells (left), CD8+ T cells (center), and CD3-CD8+ lymphocytes (right) in (e) colon and (f) MLNs were compared with damage to the structural barrier of the colon as measured by the breach (no claudin) to intact (claudin) ratio. Closed circles, SIV− colon; closed triangles, SIV+ colon; open circles, SIV− MLNs; open triangles, SIV+ MLNs. Horizontal bars represent median and diagonal lines represent linear regression.
