Table 1 Upregulated pathways in WT and N4KO mice shortly after flagellin injection

From: Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

Pathway

WT (Fold enrichment)

N4KO (Fold enrichment)

NOD-like receptor signaling pathway

16.7

18.0

Toll-like receptor signaling pathway

10.5

9.5

Cytosolic DNA-sensing pathway

8.7

9.3

Cytokine–cytokine receptor interaction

7.8

5.6

Chemokine signaling pathway

7.0

6.1

T-cell receptor signaling pathway

5.4

5.1

MAPK signaling pathway

4.5

5.2

  1. MAPK, mitogen-activated protein kinase; PBS, phosphate-buffered saline; WT, wild type.
  2. Gene expression level has been assessed by microarray using MouseWG-6 v2 chips (Affymetrix) in the colon of WT, T5KO, N4KO, and T5/N4-DKO mice 1 h after intraperitoneally flagellin injection in comparison with the matching genotype mice receiving only PBS. Upregulated genes, only observed in WT and N4KO mice, were then analyzed using the Database for Annotation, Visualization and Integrated Discovery (DAVID) tool (http://david.abcc.ncifcrf.gov/) for Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways to determine which pathways were significantly upregulated after flagellin injection.
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