Figure 2
From: IL-10 modulates DSS-induced colitis through a macrophage–ROS–NO axis
Dextran sodium sulfate (DSS)-induced colitis in interleukin (IL)-10RαMdel mice. (a) IL-10RαMdel and IL-10Rαfl/fl mice received 3% DSS for 5 days, and rectal bleeding was scored daily. (b, c) Representative photomicrographs and tallied scores for disease parameters from hematoxylin and eosin (H&E)-stained colon sections obtained 7 days after initiating DSS treatment. Scoring for individual parameters is scaled from 0 to 3 (0–12 total) and criteria are listed under Methods. Mean values for individual mice (circles) and cohorts (lines) are plotted. (d, e) Colons were removed at day 7 and colon length measured. Individual mice (circles) and cohort means (lines) are plotted. *P<0.05, **P<0.01, ***P<0.001.
