Figure 8
From: Th17-cell plasticity in Helicobacter hepaticus–induced intestinal inflammation
Model of CD4+ T-cell phenotype conversion during Helicobacter hepaticus (Hh)-induced colitis. Inoculation of disease-susceptible hosts with Hh causes CD4+ cells to differentiate into T helper type 1 (Th1) and Th17 lymphocytes. Interleukin (IL)-17A+ cells subsequently switch and transition via an interferon (IFN)-γ/IL-17A double-positive intermediate to become IFN-γ+ ex-Th17 cells. These ex-Th17 cells display similarities to Th1 cells but may also produce other pro-inflammatory mediators that contribute to the inflammatory response. AhR, aryl hydrocarbon receptor; RORγt, RAR-related orphan receptor γt; TGF, transforming growth factor.
