Figure 2
From: Mouse and human Notch-1 regulate mucosal immune responses
Effect of Notch-1 knockdown (KD) on dextran sulfate sodium (DSS)–induced colitis. (a) Percent body weight of mice treated with scrambled (Sc-DSS) or Notch-1 (N-DSS) small interfering RNA (siRNA) in conjunction with DSS treatment (acute model of DSS). (b) Histology score of the distal colon of Sc-DSS or N-DSS mice at day 8 of acute DSS treatment. (c) Percent body weight of Sc-DSS or N-DSS mice (recovery model of DSS). (d) Histology score of the distal colon of Sc-DSS or N-DSS mice at day 12 of recovery model of DSS. Data represent the mean±s.e.m. of 4–8 mice/group. P<0.05 was considered statistically significant.
