Figure 6
From: Intestinal bacteria induce TSLP to promote mutualistic T-cell responses
Thymic stromal lymphopoietin receptor (TSLPR) deficiency results in a failure to expand Foxp3+Helios− colonic regulatory T (Treg) cells in response to colonization with altered Schaedler flora (ASF) bacteria. Representative histograms and quantification of Helios−/Helios+ ratios in CD25+FoxP3+ cells from (a, c) colonic lamina propria (cLP) and (b, d) mesenteric lymph nodes (MLN) of germ-free and day 28 ASF-colonized mice. Results are pooled from three independent experiments for the cLP (n=3–4, per group per experiment) and are representative of two independent experiments for the MLN (n=3–4 per group). *P<0.05, **P<0.01, ***P<0.001.
