Figure 2
From: Lung epithelial cells are essential effectors of inducible resistance to pneumonia
Interleukin (IL)-22 is not required for Pam2-ODN-induced resistance. Il22−/− mice and wild-type littermates were inhalationally challenged with Pseudomonas aeruginosa grown to mid-log phase with or without aerosolized Pam2-ODN (oligonucleotide) pretreatment 24 h before the infectious challenge. (a) Survival of pneumonia (N=8 mice/group), (b) lung pathogen burden immediately after the infectious challenge as assessed by serial dilution culture of whole lung homogenates (N=3 mice/group). (*P<0.01 vs. phosphate-buffered saline (PBS)-treated wild-type; **P<0.03 vs. PBS-treated Il22−/−; †P>0.09 vs. Pam2-ODN-treated wild-type; ‡P<0.0001 vs. PBS-treated syngeneic mice). CFU, colony-forming units.
