Figure 4
From: Lung epithelial cells are essential effectors of inducible resistance to pneumonia
Lung epithelial myeloid differentiation primary response gene 88 (MyD88) is required for inducible resistance. Mice conditionally deficient in lung epithelial Myd88 (Myd88SPCΔ/Δ) and littermate controls (Myd88fl/fl) were inhalationally challenged with Pseudomonas aeruginosa grown to mid-log phase with or without aerosolized Pam2-ODN (oligonucleotide) pretreatment 24 h before the infectious challenge: (a) pneumonia survival (N=8 mice/group), and (b) lung pathogen burden immediately after the infectious challenge (N=3 mice/group). (c) Survival of influenza pneumonia in lung epithelial Myd88 deletants and littermate controls with or without aerosolized Pam2-ODN pretreatment 24 h before the infectious challenge. (*P<0.0005 vs. phosphate-buffered saline (PBS)-treated Myd88fl/fl; **P<0.0001 vs. Pam2-ODN-treated Myd88SPCΔ/Δ). CFU, colony-forming units.
