Figure 2 | Mucosal Immunology

Figure 2

From: Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3− T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells

Figure 2

Ex vivo phenotypic analysis of CD4+Foxp3+ and CD4+Foxp3− T cells in different compartments. Compiled flow cytometry data are shown for expression of (a) CD25, (b) cytotoxic T-lymphocyte antigen 4 (CTLA-4), (c) CD39, (d) Ki67, (e) LAG-3 and (f) CD103 among CD4+Foxp3+ Tregs (▴) and CD4+Foxp3− T cells (▪) in matched blood (peripheral blood mononuclear cells (PBMCs)), unaffected colon, and tumor samples. Foxp3, forkhead box P3. Significant differences are indicated: *P<0.05, **P<0.01, and ***P<0.001. Representative flow cytometry plots depicting the gating strategy are shown in Supplementary Figure S2 online.

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