Figure 3 | Mucosal Immunology

Figure 3

From: Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3− T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells

Figure 3

CD4+ T cells expressing latency-associated peptide (LAP) and lymphocyte activation gene-3 (LAG-3), but not forkhead box P3 (Foxp3), are enriched in colorectal tumors. (a, b) Expression of LAP on CD4+Foxp3+ Tregs (▴) and CD4+Foxp3− T cells (▪) from (a) matched blood, unaffected colon, and tumor samples, with the latter stratified as (b) Dukes’ grade A (early) and Dukes’ grade C (advanced) tumors. Significant differences are indicated: **P<0.01 and ***P<0.001. (c) Representative phenotypic analysis of CD4+LAP+ and CD4+LAP− tumor-infiltrating lymphocytes (TILs), showing expression profiles for LAG-3, CD25, and Foxp3.

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