Mucosal Immunology

NB: AS OF JANUARY 1, 2023 THIS JOURNAL IS PUBLISHED WITH ELSEVIER: https://www.sciencedirect.com/journal/mucosal-immunology

Table 1 Phenotypic overview of CD4⁺Foxp3^+/− T cells

From: Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells

		CTLA-4	LAP	LAG-3	CD39	CD103	Ki67	CD25	Helios	ICOS
Tumor	CD4⁺FoxP3⁻	++	++	++	+++	++	++	++	−	+
	CD4⁺FoxP3⁺	+++	+	+	+++	+	++	+++	+++	+++
Colon	CD4⁺FoxP3⁻	++	+	−	+++	+	−	+	−	+
	CD4⁺FoxP3⁺	+++	+	−	+++	−	+	++	++	++
PBMC	CD4⁺FoxP3⁻	−	−	−	−	−	−	−	−	+
	CD4⁺FoxP3⁺	++	−	−	++	−	++	++	+++	++

Abbreviations: CTLA-4, cytotoxic T-lymphocyte antigen 4; Foxp3, forkhead box P3; LAG-3, lymphocyte activation gene-3; LAP, latency-associated peptide; ICOS, inducible T-cell costimulator; PBMC, peripheral blood mononuclear cell.
−, Average expression <10% of cells.
+, Average expression 10–24.9% of cells.
++, Average expression 25–49.9% of cells.
+++, Average expression >50% of cells.

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