Table 3 Phenotypic overview of CD4+LAP+/− T cells

From: Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3− T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells

 

CTLA-4

Foxp3

LAG-3

CD39

CD103

Ki67

CD25

ICOS

Tumor

 CD4+LAP−

+++

++

−

+++

+

++

−

+

 CD4+LAP+

+++

+

+++

+++

++

++

+++

+

Colon

 CD4+LAP−

++

+

−

++

−

+

−

−

 CD4+LAP+

++

+

−

+++

−

+

+++

+

PBMC

 CD4+LAP−

+

−

−

−

−

−

−

+

 CD4+LAP+

+

−

−

−

−

+

+++

++

  1. Abbreviations: CTLA-4, cytotoxic T-lymphocyte antigen 4; Foxp3, forkhead box P3; LAG-3, lymphocyte activation gene-3; LAP, latency-associated peptide; ICOS, inducible T-cell costimulator; PBMC, peripheral blood mononuclear cell.
  2. −, Average expression <10% of cells.
  3. +, Average expression 10–24.9% of cells.
  4. ++, Average expression 25–49.9% of cells.
  5. +++, Average expression >50% of cells.
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