Figure 4
D-series resolvins RvD1 and aspirin-triggered RvD1 (AT-RvD1) reduce histamine (His)-stimulated increase in high molecular weight glycoconjugate secretion in conjunctival goblet cells. Block of 2-h histamine (10−5 M)-stimulated high molecular weight glycoconjugate secretion in (a) human and (b, c) rat conjunctival goblet cells by a 30-min previous exposure of RvD1 or AT-RvD1. Panel a indicates mean of four experiments using increasing concentrations of RvD1 (closed circles) and AT-RvD1 (open circles). Mean of four experiments with stimulation by histamine at 10−6 M (open circles) and 10−5 M (closed circles) after 30 min exposure to RvD1 (b) and AT-RvD1 (c). *P<0.05 (histamine vs. resolvin plus histamine).
