Figure 4
From: Foxp3+ regulatory T cells promote lung epithelial proliferation
Adoptive transfer (AT) of regulatory T cells (Tregs) augments epithelial proliferation after acute lung injury (ALI) in Rag-1−/− mice. AT of wild-type (WT) Tregs augments epithelial proliferation after ALI in Rag-1−/− mice. Rag-1−/− mice were challenged with intratracheal lipopolysaccharide (IT LPS) and 1 h afterward received 1 × 106 WT CD4+CD25+, WT CD4+CD25− or CD103−/−CD4+CD25+ cells and lungs collected at day 7 post LPS administration. (a) Percentage of proliferating CD326+ki-67+ epithelial cells at day 7 post LPS in WT mice or Rag-1−/− mice after infusion of designated lymphocytes subsets (n=6–12 per group). (b) Total number of Foxp3+ cells in the lungs of WT mice or Rag-1−/− mice after infusion of designated lymphocytes subsets (n=4–7 per group). P-values determined by Student’s t-test.
