Table 1 Expression analysis of fibrosis mediators in the adoptive transfer colitis model

	Baseline	Pre-Tx	Iso Ab	Tl1a Ab-80 mg kg ⁻¹
	% β-Actin	% β-Actin	% β-Actin	% β-Actin	P vs.
	n =6	n =6	n =7	n =6	Rag	Pre-Tx	Iso Ab
col1a1	0.19±0.12	0.19±0.12	0.21±0.10	0.11±0.03	NS	0.024	0.03
col1a2	0.49±0.29	0.76±0.32	1.23±0.78	0.39±0.12	NS	0.024	0.026
col3a1	12.69±3.61	16.45±3.93	16.08±4.04	9.66±3.44	NS	0.0073	0.014
col4a1	1.54±0.32	1.95±0.32	1.88±0.84	1.19±0.33	NS	0.00055	NS
Tgfβ1	0.16±0.06	0.40±0.16	0.50±0.17	0.25±0.06	0.018	0.046	0.003
Ctgf	0.66±0.13	1.04±0.40	1.04±0.32	0.54±0.08	NS	0.021	0.007
Igf1	0.32±0.06	0.53±0.18	0.73±0.36	0.41±0.15	NS	NS	0.047
Pten	3.80±0.75	2.28±0.53	1.86±0.25	2.03±0.67	0.0015	NS	NS
Il31Ra	0.003±0.001	0.005±0.002	0.007±0.003	0.004±0.001	NS	NS	0.034
Mmp2	0.32±0.072	0.43±0.12	0.44±0.13	0.28±0.07	NS	0.015	0.015
Mmp3	0.046±0.022	1.15±1.15	1.18±0.70	0.34±0.37	0.043	NS	0.036
Mmp13	0.047±0.015	0.20±0.17	0.18±0.08	0.10±0.06	NS	NS	NS
Timp1	0.038±0.014	0.19±0.24	0.18±0.12	0.14±0.07	0.016	NS	NS
Timp2	1.11±0.27	0.86±0.15	0.79±0.12	0.59±0.18	0.001	0.001	0.048

Ab, antibody; ctgf, connective tissue growth factor; Igf1, insulin-like growth factor-1; mmp, metalloprotease; NS, not significant; timp, tissue inhibitors of metalloprotease; tgfβ1, transforming growth factor β1.

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