Figure 8

Model of pDC modulation on Th17 differentiation during B. pertussis infection. pDC accumulation and secretion of IFNα in the lungs inhibit Th17 differentiation during infection, limiting an early appearance of Th17 cells, and compromises resolution of B. pertussis early during infection. IFN, interferon; pDC, plasmacytoid dendritic cell; Th, T helper.