Figure 5
From: Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways
Schematic illustration of the transcriptional network. Transcriptional network of interleukin-4 (IL-4; left)- and interferon-γ (IFN-γ)-induced transcription factors (right) and genes of the IL-4/IFN-γ antagonism of epithelial cells. The network connects genes that are known to be transcriptionally regulated or that contain transcription factor binding sites (Genomatix database) of the respective factor. Green lines originate from IL-4- and red lines from IFN-γ-induced transcription factors. Black lines show intertranscription factor connections. The figure shows numerous intertranscription factor lines that may be critical for polarized gene regulation. GATA3 appears to be connected to many type 2, and also several type 1 genes. On the side of IFN-γ-induced transcription factors it appears that TEAD4, MEF2C, and ZEB1 have hub character, whereas TBX21 is connected with only a few genes.
