Figure 3
Hematopoietic cell-derived complement is required for colitis-associated cancer (CAC) carcinogenesis. Bone marrow (BM) chimeric mice from (a) C3−/− and (b) C5aR−/− rodents were generated and subjected to azoxymethane/dextran sulfate sodium (AOM+DSS) treatment as described in the Methods. Colons were removed on day 60, and tumor number was counted. The bars represent the median of each group. Each group consists of 8 to 10 mice. ** P<0.01. WT, wild type.
