Figure 8
Signal transducer and activator of transcription factor-1 (STAT1) activation and CXCL10 expression are increased during gastrointestinal (GI) graft-versus-host disease (GVHD) in patients in both intestinal epithelial cells and mononuclear cells of the lamina propria around altered crypts. (a–g) STAT1 phosphorylation and CXCL10 expression are observed in cells from patients with severe GI acute GVHD (aGVHD), but not control patients. (a–c) Representative immunohistochemistry of phosphorylated STAT1 (P-STAT1) in the GI tissue (original magnification, × 200 for a and b, and × 400 for c). (d) Expression of P-STAT1 is represented. (e,g) Representative immunohistochemistry of CXCL10 in GI tissue (original magnification × 200 for e and f). (g) Expression of CXCL10 is represented.
