Figure 6
Batf3-dependent dendritic cells (DCs) are dispensable for the production of interleukin-23 (IL-23) in Helicobacter hepaticus (Hh)-driven colitis. Wild-type (WT) and Batf3−/− mice were infected with Hh combined with anti-IL-10R monoclonal antibody (mAb) treatment and analyzed after 2 weeks alongside uninfected controls (Ctrl). (a) Representative fluorescence-activated cell sorting (FACS) plots and (b) frequencies and numbers of CD103+ CD11b- and CD103+ CD11b+ cells among CD45+ colonic leukocytes. (c) Total number of lamina propria cells per mouse. (d) Histopathology scores of the colon. Data points represent individual mice, bars indicate medians. *P<0.05 as determined by Mann–Whitney U-test, NS, not significant.
