Figure 1
Low intra-individual microbial diversity in common variable immunodeficiency (CVID) patients. (a) Alpha diversity (Chao1) in controls and patients with CVID and inflammatory bowel disease (IBD) showed in median quartiles and range. The comparison is made by using t-test and significant P-value is marked as ***P<0.001, **P<0.01, *P<0.05. (b) Beta diversity plot colored by disease phenotype (unweighted unifrac distance). A principal coordinate plots of the unweighted unifrac distance, where each point represents a single sample colored by phenotype. The distance between points represents how compositionally different the samples are from one another. PC1, PC2, and PC3 represent the three principal coordinates that capture most of the diversity (fraction of diversity captured shown in percent). (c) The same principal coordinate plot as in (b), but the samples are now colored according to the alpha diversity measure Chao1.
