Figure 4
Increased lipopolysaccharide (LPS) in common variable immunodeficiency (CVID) patients correlates with altered gut microbiota. (a) LPS levels in an expanded CVID patient cohort (n=104) compared with healty controls (n=30) showed in median, quartiles, and range. (b) LPS levels in “Infection only”, “Complications”, and Controls shown in median, quartiles, and range. (c) Alpha diversity Chao1 correlates with LPS. (d) Dysbiosis index correlates with LPS. The comparisons are made by Mann–Whitney U test or Spearman’s rank correlation test, as appropriate. Significant P-values are marked as ***P<0.001, **P<0.01, *P<0.05. Rho refers to Spearman’s rank correlation coefficient.
