Figure 2
From: A key requirement for CD300f in innate immune responses of eosinophils in colitis
Dynamic regulation of CD300f expression in colitis. Colonic expression of CD300f in control individuals, active UC patients and UC patients in remission is shown (a). Temporal expression of murine CD300 family members in total colonic tissue of DSS-treated mice as determined by analysis of deposited microarray data (Geo Profiles ID: 70456009) (b). Surface expression of human (c) and murine CD300f (d, e) and CD300a (e, g) in peripheral blood (d, e) and single cell suspensions of colonic lamina propria cells (c, f, g). In (b), expression data were obtained from five mice per time point. CD300a and CD300f surface expression in human colonic cells (c) was obtained from nine patients. In (d–g), surface expression of murine CD300a and CD300f is from three to five mice per time point. In (h), total counts of immune cells in the colon are shown. The red line represents the threshold expression level (i.e., the value 1). *P<0.05, **P<0.01, ***P<0.001. DSS, dextran sodium sulfate; UC, ulcerative colitis.
