Figure 5
From: A key requirement for CD300f in innate immune responses of eosinophils in colitis
The expression of CD300f in inflammatory monocytes is dispensible for the development of colitis. WT and Cd300f −/− mice were treated with 2% DSS in their drinking water. To deplete inflammatory monocytes, DSS-treated mice were injected with anti-CCR2 antibody (MC21). The levels of peripheral blood (a) and colonic monocytes (b) as well as colonic eosinophils (c) is shown. DSS-treated and MC21-injected animals were assessed for weight loss (d) and disease activity index (e). Data are from n=10–11 mice per group, *P<0.05; **P<0.01; ***P<0.001. DSS, dextran sodium sulfate; WT, wild type.
