Figure 2

CD4+ T cells mount a rapid and robust T-helper type 17 (Th17) recall responses in the lung. (a) Percentage and (b) absolute number of pulmonary CD4 and CD8 T cells in naïve mice, mice infected with T4 only (T4), or P1121-immune mice challenged with T4 (P1121-T4) on day 7 after T4. Interleukin-17A (IL-17A) and interferon-γ (IFN-γ) production by CD4+ and CD8+ T cells after stimulation with heat-killed T4 as (c) visualized by FACS and (d) calculated as the number of CD4+IL-17A+, CD4+IFN-γ+, and CD8+IFN-γ+ per lung.