Figure 4
Gene expression (mRNA) changes in nasal curettage samples with respect to interleukin (IL)-5 and IL-13 protein levels. Dot plots of allergen-induced GMTWA2–8h (geometric mean time-weighted average cytokine concentration measured by immunoassay at 2–8 h) log fold change from baseline in nasal lining fluid IL-5 and IL-13 compared with (a) first principal component coefficient of nasal scrape gene expression for subjects pretreated with placebo and (b) baseline nasal scrape IL-33 mRNA expression. Green squares and purple cross characters correspond to cytokine responders and non-responders, respectively. Pearson’s and Spearman’s correlation coefficients for the relationships appear above the respective dot plots.
