Figure 3
Donor microbiome predominates treatment condition and influences gut physiology. (a) Reciprocal transplant of microbiota preserves distinctness of microbial composition, which is closer to the donor microbiome, rather than the treatment condition (placebo or morphine alone; b). (c) This physiologically translates to gut pathologies associated with morphine-induced dysbiotic microbiome, e.g., transplantation of morphine-induced dysbiotic microbiome into healthy wild-type (WT) animals results in “morphine-like” diseased phenotype, very similar to morphine-implanted donor animals, whereas transplantation of “normal” microbiome into morphine-treated animals shows distinct improvement in the gut pathology. Arrows indicate sites of gut injury.
