Figure 6
The expression of ITLN1 is increased in the airway and plasma of subjects with asthma, and is correlated with induced sputum eosinophils. (a) The transcript levels of ITLN1 in bronchial brushings of subjects with asthma (n=48) and healthy controls (n=32) were determined by quantitative PCR. Values were relative to median value of healthy controls and were log2 transformed. (b) Immunohistochemistry of ITLN1 in epithelium and submucosal gland in representative sections of bronchial biopsies from subjects with asthma and healthy controls. Original magnification, × 400. Correlation between ITLN1 transcript levels and (c) IL-25 transcript levels in bronchial brushings, and (d) the percentage of eosinophils in induced sputum of subjects with asthma (n=48) and healthy control (n=23). (e) Sputum ITLN1 protein levels of subjects with asthma (n=24) and healthy controls (n=9) were determined by ELISA. (f) Correlation between sputum ITLN1 protein levels and the percentage of eosinophils in induced sputum of subjects with asthma (n=24) and healthy control (n=9). (g) Plasma ITLN1 protein levels of subjects with asthma (n=48) and healthy controls (n=32) were determined by ELISA.
