Figure 1
Fungal persistence in the host inversely correlates with transient weight loss of infected animals at the onset of infection. WT mice were infected with C. albicans SC5314, Cag, 529L, or 101. (a) Tongue fungal burden on day 1. (b) Representative images of sagittal tongue sections (day 1) stained with PAS. Arrows: inflammatory infiltrates. Scale bars: 50 μm. Inset: 2-fold magnification. (c) Representative transmission electron microscopy images of infected tongues (day 1). Red circles: fungal penetration of cell membranes in the stratum corneum. Scale bars: 5 μm. (d) Body weight of infected mice. (e,f) Tongue fungal burden on day 3 and day 7. (g) Representative images of sagittal tongue sections (day 7) stained with PAS. Scale bars: 100 μm. In a, e, f, each symbol represents one mouse. Data are the pool of two independent experiments. The geometric mean and significant differences between each group and the SC5314-infected group are indicated. In d, data are the mean+s.d., n=6, pooled from two independent experiments. Significant differences between groups infected with SC5314 and Cag, 529L or 101 are indicated with #, † or *, respectively. PAS, periodic-acid Shiff; WT, wild type.
